Pub. Date : 1999 Dec 16
PMID : 10836047
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 7-Azabicycloheptane carboxylic acid: a proline replacement in a boroarginine thrombin inhibitor. | Proline | coagulation factor II, thrombin | Homo sapiens |
| 2 | [formula: see text] The synthesis of thrombin inhibitor 3, which incorporates conformationally constrained 7-azabicycloheptane carboxylic acid (1) as a proline replacement, is described. | Proline | coagulation factor II, thrombin | Homo sapiens |
| 3 | The inhibition constant (Ki(thrombin) = 2.9 nM) indicates that 1 is a reasonable replacement of proline in the formation of a beta-turn tripeptide mimetic. | Proline | coagulation factor II, thrombin | Homo sapiens |