Pub. Date : 2000 Jun
PMID : 10834937
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show that TPA inhibits the activation of secreted latent TGF-beta, thus decreasing the concentration of active TGF-beta to which the cells are exposed. | Tetradecanoylphorbol Acetate | transforming growth factor beta 1 | Homo sapiens |
| 2 | We show that TPA inhibits the activation of secreted latent TGF-beta, thus decreasing the concentration of active TGF-beta to which the cells are exposed. | Tetradecanoylphorbol Acetate | transforming growth factor beta 1 | Homo sapiens |
| 3 | In contrast, a reduction in the TGF-beta concentration, to a range of 0.14-0.20 x 10(-2) ng/ml (which is similar to that measured in TPA-treated cells), mimics TPA-induced differentiation. | Tetradecanoylphorbol Acetate | transforming growth factor beta 1 | Homo sapiens |
| 4 | In contrast, a reduction in the TGF-beta concentration, to a range of 0.14-0.20 x 10(-2) ng/ml (which is similar to that measured in TPA-treated cells), mimics TPA-induced differentiation. | Tetradecanoylphorbol Acetate | transforming growth factor beta 1 | Homo sapiens |
| 5 | By impairing the TGF-beta autocrine loop, TPA stabilizes the factor concentration within the range compatible for differentiation to occur. | Tetradecanoylphorbol Acetate | transforming growth factor beta 1 | Homo sapiens |
| 6 | In contrast, in human primary muscle cells a much higher concentration of exogenous TGF-beta is required for the differentiation inhibitory effect and TPA inhibits differentiation in these cells probably through a TGF-beta independent mechanism. | Tetradecanoylphorbol Acetate | transforming growth factor beta 1 | Homo sapiens |