Title : Prostaglandin E(2) regulation of cyclooxygenase expression in keratinocytes is mediated via cyclic nucleotide-linked prostaglandin receptors.

Pub. Date : 2000 Jun

PMID : 10828079






4 Functional Relationships(s)
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1 In primary keratinocytes transiently transfected with a full-length COX-2 promoter linked to a luciferase reporter gene, we observed enhanced transcription by AA, PGE(2), and the other prostaglandins. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 SQ 22536, an adenylate cyclase inhibitor, inhibited COX-2 mRNA induction by PGE(2) in a dose-dependent manner suggesting that PGE(2)-induced expression may be through one of the cAMP-linked PGE(2) receptors. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 SQ 22536, an adenylate cyclase inhibitor, inhibited COX-2 mRNA induction by PGE(2) in a dose-dependent manner suggesting that PGE(2)-induced expression may be through one of the cAMP-linked PGE(2) receptors. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
4 SQ 22536, an adenylate cyclase inhibitor, inhibited COX-2 mRNA induction by PGE(2) in a dose-dependent manner suggesting that PGE(2)-induced expression may be through one of the cAMP-linked PGE(2) receptors. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens