Title : Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450.

Pub. Date : 2000 Apr

PMID : 10821163






2 Functional Relationships(s)
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1 Diethyldithiocarbamate, orphenadrine and furafylline were shown separately to be less selective inhibitors of CYP2E1, CYP2B6 and CYP1A isoforms by a broad range of IC50 that overlap those observed with other P450 isoforms. Ditiocarb cytochrome P450 family 2 subfamily B member 6 Homo sapiens
2 Diethyldithiocarbamate, orphenadrine and furafylline were shown separately to be less selective inhibitors of CYP2E1, CYP2B6 and CYP1A isoforms by a broad range of IC50 that overlap those observed with other P450 isoforms. Ditiocarb cytochrome P450 family 2 subfamily B member 6 Homo sapiens