Title : Thiol-reactive metal compounds inhibit NF-kappa B activation by blocking I kappa B kinase.

Pub. Date : 2000 Jun 1

PMID : 10820281






1 Functional Relationships(s)
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1 Two catalytic subunits of IKK complex, IKK alpha and IKK beta, were both inhibited by these thiol-modifying agents, suggesting the presence of a cysteine sulfhydryl group in these subunits, which is critical for enzyme activity. Cysteine conserved helix-loop-helix ubiquitous kinase Mus musculus