Pub. Date : 2000 Jun
PMID : 10820139
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Modafinil inhibited the 4"-hydroxylation of S-mephenytoin, a marker substrate for CYP2C19, reversibly and competitively with a K(i) value of 39 microM, which approximates the steady-state C(max) value of modafinil in human plasma at a dosage of 400 mg/day. | Modafinil | cytochrome P450 family 2 subfamily C member 19 | Homo sapiens |
| 2 | Overall, modafinil was shown to have effects on human hepatic CYP1A2, CYP2B6, CYP2C9, CYP2C19, and CYP3A4/5 activities in vitro. | Modafinil | cytochrome P450 family 2 subfamily C member 19 | Homo sapiens |