Pub. Date : 2000 May 19
PMID : 10818238
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It is known that histamine suppresses gene expression and synthesis of tumor necrosis factor alpha (TNF-alpha) induced by lipopolysaccharide (LPS) in human peripheral blood mononuclear monocytes (HPM) or alveolar macrophages via histamine H2 receptors. | Histamine | tumor necrosis factor | Homo sapiens |
| 2 | It is known that histamine suppresses gene expression and synthesis of tumor necrosis factor alpha (TNF-alpha) induced by lipopolysaccharide (LPS) in human peripheral blood mononuclear monocytes (HPM) or alveolar macrophages via histamine H2 receptors. | Histamine | tumor necrosis factor | Homo sapiens |
| 3 | We investigated the effect of histamine and differentiation in macrophages on the expression and secretion of TNF-alpha, TNF-alpha-converting enzyme (TACE), and histamine H1 and H2 receptors by use of a leukemia cell line, U937, and HPM. | Histamine | tumor necrosis factor | Homo sapiens |
| 4 | Differentiation of U937 and HPM cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) enhanced the H1 receptor expression and rather suppressed the H2 receptor, resulting in up-regulation of the histamine-induced expression and secretion of TNF-alpha, modulated via TACE. | Histamine | tumor necrosis factor | Homo sapiens |