Title : Switch of histamine receptor expression from H2 to H1 during differentiation of monocytes into macrophages.

Pub. Date : 2000 May 19

PMID : 10818238






1 Functional Relationships(s)
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1 Differentiation of U937 and HPM cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) enhanced the H1 receptor expression and rather suppressed the H2 receptor, resulting in up-regulation of the histamine-induced expression and secretion of TNF-alpha, modulated via TACE. Histamine ADAM metallopeptidase domain 17 Homo sapiens