Title : Formation and persistence of O(6)-methylguanine in the mouse colon following treatment with 1,2-dimethylhydrazine as measured by an O(6)-alkylguanine-DNA alkyltransferase inactivation assay.

Pub. Date : 2000 Jun 5

PMID : 10814890






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Formation and persistence of O(6)-methylguanine in the mouse colon following treatment with 1,2-dimethylhydrazine as measured by an O(6)-alkylguanine-DNA alkyltransferase inactivation assay. O-(6)-methylguanine O-6-methylguanine-DNA methyltransferase Mus musculus
2 O(6)-Methylguanine (O(6)-MeG) levels, measured using a simple [3H]-based O(6)-alkylguanine-DNA alkyltransferase (ATase) inactivation assay, ranged from 0.6 to 16.7 fmol/microg DNA with: (i) highest levels in the distal colon; and (ii) higher levels after 68 mg/kg total DMH than 6.8 mg/kg DMH. O-(6)-methylguanine O-6-methylguanine-DNA methyltransferase Mus musculus