Title : The role of the pleckstrin homology domain in membrane targeting and activation of phospholipase Cbeta(1).

Pub. Date : 2000 May 19

PMID : 10809731






2 Functional Relationships(s)
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1 PLCbeta(1)-PH was found to bind phosphatidylinositol 3-phosphate most strongly, whereas other phosphoinositides were bound with lower affinity. phosphatidylinositol 3-phosphate phospholipase C beta 1 Homo sapiens
2 These results demonstrate that a cooperative mechanism involving phosphatidylinositol 3-phosphate and the Gbetagamma subunit regulates the plasma membrane localization and activation of PLCbeta(1)-PH. phosphatidylinositol 3-phosphate phospholipase C beta 1 Homo sapiens