Title : A functional analysis of EP4 receptor-expressing neurons in mediating the action of prostaglandin E2 within specific nuclei of the brain in response to circulating interleukin-1beta.

Pub. Date : 2000 May

PMID : 10800959






2 Functional Relationships(s)
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1 In a first set of experiments, animals were treated with the inhibitor of PG synthesis ketorolac to determine the endogenous contribution of PG in mediating the neuronal activation and EP4 expression in response to circulating interleukin-1beta(IL-1beta). Prostaglandins interleukin 1 beta Rattus norvegicus
2 Both intracerebroventricular PGE2 and intravenous IL-1beta injection provoked a sharp and rapid increase in plasma corticosterone levels, an effect that was completely prevented in inhibiting PG production in IL-1beta-challenged rats. Prostaglandins interleukin 1 beta Rattus norvegicus