Title : Presynaptic impairment of cerebellar inhibitory synapses by an autoantibody to glutamate decarboxylase.

Pub. Date : 2000 Apr 1

PMID : 10785255






5 Functional Relationships(s)
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Protein Name
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1 Glutamic acid decarboxylase (GAD), the enzyme responsible for converting glutamate to gamma-aminobutyric acid (GABA), is a target of humoral autoimmunity in stiff-man syndrome and subacute cerebellar ataxia. gamma-Aminobutyric Acid glutamate decarboxylase 1 Homo sapiens
2 Glutamic acid decarboxylase (GAD), the enzyme responsible for converting glutamate to gamma-aminobutyric acid (GABA), is a target of humoral autoimmunity in stiff-man syndrome and subacute cerebellar ataxia. gamma-Aminobutyric Acid glutamate decarboxylase 1 Homo sapiens
3 Glutamic acid decarboxylase (GAD), the enzyme responsible for converting glutamate to gamma-aminobutyric acid (GABA), is a target of humoral autoimmunity in stiff-man syndrome and subacute cerebellar ataxia. gamma-Aminobutyric Acid glutamate decarboxylase 1 Homo sapiens
4 Glutamic acid decarboxylase (GAD), the enzyme responsible for converting glutamate to gamma-aminobutyric acid (GABA), is a target of humoral autoimmunity in stiff-man syndrome and subacute cerebellar ataxia. gamma-Aminobutyric Acid glutamate decarboxylase 1 Homo sapiens
5 Recently, we found that an anti-GAD autoantibody in the CSF of an ataxic patient selectively suppressed GABA-mediated transmission on cerebellar Purkinje cells without affecting glutamate-mediated transmission. gamma-Aminobutyric Acid glutamate decarboxylase 1 Homo sapiens