Title : The inhibition of ERK/MAPK not the activation of JNK/SAPK is primarily required to induce apoptosis in chronic myelogenous leukemic K562 cells.

Pub. Date : 2000 Jun

PMID : 10781688






2 Functional Relationships(s)
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1 In HL-60 cells, sorbitol-induced apoptosis was prevented by the treatment of phorbol myristate 13-acetate (PMA), which activates the ERK/MAPK pathway, and this was blocked by PD98059. phorbol myristate 13-acetate mitogen-activated protein kinase 1 Homo sapiens
2 In HL-60 cells, sorbitol-induced apoptosis was prevented by the treatment of phorbol myristate 13-acetate (PMA), which activates the ERK/MAPK pathway, and this was blocked by PD98059. phorbol myristate 13-acetate mitogen-activated protein kinase 1 Homo sapiens