Title : Thrombopoietin increases platelet sensitivity to alpha-thrombin via activation of the ERK2-cPLA2 pathway.

Pub. Date : 2000 Apr

PMID : 10780326






1 Functional Relationships(s)
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1 The effect of TPO was abolished by indomethacin and caused by synergism with signal generation by alpha-thrombin at the level of the cytosolic phospholipase A2 (cPLA2) pathway resulting in more arachidonate release, cPLA2 phosphorylation and thromboxane A2 formation. Arachidonic Acid coagulation factor II, thrombin Homo sapiens