Pub. Date : 2000 May 1
PMID : 10779799
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Kinetics and mechanism of ATP-dependent IL-1 beta release from microglial cells. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 2 | Addition of extracellular ATP to LPS-primed microglia caused a burst of release of a large amount of processed IL-1 beta. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 3 | In LPS-treated cells, ATP slightly increased the synthesis of pro-IL-1 beta. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 4 | Optimal ATP concentration for IL-1 beta secretion was between 3 and 5 mM, but significant release could be observed at concentrations as low as 1 mM. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 5 | At all ATP concentrations IL-1 beta release could be inhibited by increasing the extracellular K+ concentration. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 6 | ATP-dependent IL-1 beta release was also inhibited by 90 and 60% by the caspase inhibitors YVAD and DEVD, respectively. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |