Title : The extracellular signal-regulated kinase cascade is required for NMDA receptor-independent LTP in area CA1 but not area CA3 of the hippocampus.

Pub. Date : 2000 May 1

PMID : 10777769






2 Functional Relationships(s)
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1 However, incubation of slices with forskolin, an activator of the cAMP-dependent protein kinase (PKA) cascade, did result in increases in active ERK and cAMP response element-binding protein (CREB) phosphorylation in area CA3. Colforsin mitogen-activated protein kinase 1 Homo sapiens
2 The forskolin-induced increase in active ERK was inhibited by U0126, whereas the increase in CREB phosphorylation was not, which suggests that in area CA3 the PKA cascade is not coupled to CREB phosphorylation via ERK. Colforsin mitogen-activated protein kinase 1 Homo sapiens