Pub. Date : 2000 Apr 28
PMID : 10777553
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T(84) cells is mediated by intracellular Ca2+, PYK-2, and p60(src). | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 2 | Ca(2+)-dependent agonists, such as carbachol (CCh), stimulate epidermal growth factor receptor (EGFR) transactivation and mitogen-activated protein kinase activation in T(84) intestinal epithelial cells. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 3 | Ca(2+)-dependent agonists, such as carbachol (CCh), stimulate epidermal growth factor receptor (EGFR) transactivation and mitogen-activated protein kinase activation in T(84) intestinal epithelial cells. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 4 | Ca(2+)-dependent agonists, such as carbachol (CCh), stimulate epidermal growth factor receptor (EGFR) transactivation and mitogen-activated protein kinase activation in T(84) intestinal epithelial cells. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 5 | Ca(2+)-dependent agonists, such as carbachol (CCh), stimulate epidermal growth factor receptor (EGFR) transactivation and mitogen-activated protein kinase activation in T(84) intestinal epithelial cells. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 6 | Here, we investigated mechanisms underlying CCh-stimulated epidermal growth factor receptor (EGFR) transactivation. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 7 | Here, we investigated mechanisms underlying CCh-stimulated epidermal growth factor receptor (EGFR) transactivation. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 8 | CCh (100 microM) stimulated tyrosine phosphorylation and association of the Ca(2+)-dependent tyrosine kinase, PYK-2, with the EGFR, which was inhibited by the Ca(2+) chelator, BAPTA (20 microM). | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 9 | The calmodulin inhibitor, fluphenazine (50 microM) inhibited CCh-stimulated PYK-2 association with the EGFR and phosphorylation of EGFR and ERK. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 10 | The calmodulin inhibitor, fluphenazine (50 microM) inhibited CCh-stimulated PYK-2 association with the EGFR and phosphorylation of EGFR and ERK. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 11 | CCh also induced tyrosine phosphorylation of p60(src) and association of p60(src) with both PYK-2 and the EGFR. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 12 | The Src family kinase inhibitor, PP2 (20 nM-20 microM) attenuated CCh-stimulated EGFR and ERK phosphorylation and potentiated chloride secretory responses to CCh. | Carbachol | epidermal growth factor receptor | Homo sapiens |
| 13 | We conclude that CCh-stimulated transactivation of the EGFR is mediated by a pathway involving elevations in intracellular Ca(2+), calmodulin, PYK-2, and p60(src). | Carbachol | epidermal growth factor receptor | Homo sapiens |