Title : Inhibition of cytokine secretion from human leukemic mast cells and basophils by H1- and H2-receptor antagonists.

Pub. Date : 2000 Apr

PMID : 10772385






1 Functional Relationships(s)
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1 All antihistamines caused a dose-dependent inhibition of TNF-alpha release from HMC-1 cells, with maximal effects at 10(-12) M for azelastine, 10(-9) M for loratadine and cetirizine, and 10(-8) M for ranitidine. Loratadine tumor necrosis factor Homo sapiens