Pub. Date : 2000 Apr
PMID : 10772385
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In order to confirm and expand these studies, we have compared several H1-blockers and the H2-blocker ranitidine for their effect on TNF-alpha, IL-3, 6, 8 and GM-CSF release from human leukemic mast (HMC-1) and basophilic (KU812) cells, compared to dexamethasone. | Ranitidine | tumor necrosis factor | Homo sapiens |
| 2 | All antihistamines caused a dose-dependent inhibition of TNF-alpha release from HMC-1 cells, with maximal effects at 10(-12) M for azelastine, 10(-9) M for loratadine and cetirizine, and 10(-8) M for ranitidine. | Ranitidine | tumor necrosis factor | Homo sapiens |
| 3 | Dexamethasone inhibited all cytokines, but ranitidine only TNF-alpha and IL-3. | Ranitidine | tumor necrosis factor | Homo sapiens |