Title : Identification of the major human liver cytochrome P450 isoform(s) responsible for the formation of the primary metabolites of ziprasidone and prediction of possible drug interactions.

Pub. Date : 2000

PMID : 10771452






1 Functional Relationships(s)
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1 IC50 values for the inhibition of specific probe substrates for CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4, by ziprasidone, risperidone and 9-hydroxyrisperidone were also determined using human liver microsomes from three subjects. Paliperidone Palmitate cytochrome P450 family 1 subfamily A member 2 Homo sapiens