Title : Identification of the major human liver cytochrome P450 isoform(s) responsible for the formation of the primary metabolites of ziprasidone and prediction of possible drug interactions.

Pub. Date : 2000

PMID : 10771452






4 Functional Relationships(s)
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1 AIMS: To identify the cytochrome P450 (CYP) isoform(s) responsible for the formation of the primary metabolite of ziprasidone (ziprasidone sulphoxide), to determine the kinetics of its formation and to predict possible drug interactions by investigating CYP isoform inhibition in an in vitro study. Ziprasidone Sulfoxide cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 AIMS: To identify the cytochrome P450 (CYP) isoform(s) responsible for the formation of the primary metabolite of ziprasidone (ziprasidone sulphoxide), to determine the kinetics of its formation and to predict possible drug interactions by investigating CYP isoform inhibition in an in vitro study. Ziprasidone Sulfoxide cytochrome P450 family 4 subfamily F member 3 Homo sapiens
3 AIMS: To identify the cytochrome P450 (CYP) isoform(s) responsible for the formation of the primary metabolite of ziprasidone (ziprasidone sulphoxide), to determine the kinetics of its formation and to predict possible drug interactions by investigating CYP isoform inhibition in an in vitro study. Ziprasidone Sulfoxide cytochrome P450 family 4 subfamily F member 3 Homo sapiens
4 RESULTS: Three CYP-mediated metabolites - ziprasidone sulphoxide, ziprasidone sulphone and oxindole acetic acid - were identified. Ziprasidone Sulfoxide cytochrome P450 family 4 subfamily F member 3 Homo sapiens