Title : DNA repair: counteragent in mutagenesis and carcinogenesis-- accomplice in cancer therapy resistance.

Pub. Date : 2000 Apr

PMID : 10767621






1 Functional Relationships(s)
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1 Accordingly, G:C-->A:T transitions resulting from the misreplication of an O(6)-methylated guanine at the second position of codon 12 (GGA) of H-ras represent a frequent "signature" mutation in rat mammary adenocarcinomas that develop after exposure to N-methyl-N-nitrosourea. Methylnitrosourea HRas proto-oncogene, GTPase Rattus norvegicus