Pub. Date : 2000 Jun 16
PMID : 10764743
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Stepwise assembly of a glucocorticoid receptor.hsp90 heterocomplex resolves two sequential ATP-dependent events involving first hsp70 and then hsp90 in opening of the steroid binding pocket. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 2 | Stepwise assembly of a glucocorticoid receptor.hsp90 heterocomplex resolves two sequential ATP-dependent events involving first hsp70 and then hsp90 in opening of the steroid binding pocket. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 3 | Two proteins, hsp90 and hsp70, are required for the activation of steroid binding activity that occurs with heterocomplex assembly, and three proteins, Hop, hsp40, p23, act as co-chaperones that enhance activation and assembly (Morishima, Y., Kanelakis, K. C., Silverstein, A.M., Dittmar, K. D., Estrada, L., and Pratt, W. B. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 4 | hsp90 is required for opening of the steroid binding pocket and is converted to its ATP-dependent conformation during this second step. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 5 | This conversion initiates the opening of the hydrophobic steroid binding pocket such that it can now accept the hydrophobic binding form of hsp90, which in turn must be converted to its ATP-dependent conformation for the pocket to be accessible by steroid. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 6 | This conversion initiates the opening of the hydrophobic steroid binding pocket such that it can now accept the hydrophobic binding form of hsp90, which in turn must be converted to its ATP-dependent conformation for the pocket to be accessible by steroid. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |