Title : ERK1 and ERK2 activation by chemotactic factors in human eosinophils is interleukin 5-dependent and contributes to leukotriene C(4) biosynthesis.

Pub. Date : 2000 Apr 14

PMID : 10753897






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In this study, we report that, following IL-5 priming of eosinophils, chemotactic agents including fMet-Leu-Phe, IL-8, and RANTES, promote vigorous transient activation of ERK1 and ERK2. N-Formylmethionine Leucyl-Phenylalanine mitogen-activated protein kinase 1 Homo sapiens
2 The biological relevance of ERK activation to IL-5 priming is supported by the observation that inhibition of ERK activity by treatment with the MEK inhibitors PD98059 or U0126 inhibited the release of leukotriene C(4) stimulated by fMet-Leu-Phe in IL-5-primed eosinophils. N-Formylmethionine Leucyl-Phenylalanine mitogen-activated protein kinase 1 Homo sapiens
3 The biological relevance of ERK activation to IL-5 priming is supported by the observation that inhibition of ERK activity by treatment with the MEK inhibitors PD98059 or U0126 inhibited the release of leukotriene C(4) stimulated by fMet-Leu-Phe in IL-5-primed eosinophils. N-Formylmethionine Leucyl-Phenylalanine mitogen-activated protein kinase 1 Homo sapiens