Title : N-3-substituted imidazoquinazolinones: potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction.

Pub. Date : 2000 Apr 6

PMID : 10753463






2 Functional Relationships(s)
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1 Phosphodiesterase type 5 (PDE5) inhibitors with improved PDE isozyme selectivity relative to sildenafil may result in agents for the treatment of male erectile dysfunction (MED) with a lower incidence of PDE-associated adverse effects. Sildenafil Citrate phosphodiesterase 5A Homo sapiens
2 This paper describes the discovery of 14, a PDE5 inhibitor with improved potency and selectivity in vitro compared to sildenafil. Sildenafil Citrate phosphodiesterase 5A Homo sapiens