Title : Subchronic administration of phenobarbital alters the mutation spectrum of lacI in the livers of Big Blue transgenic mice.

Pub. Date : 2000 Mar 14

PMID : 10751624






3 Functional Relationships(s)
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1 It is postulated that the increase in transversions at G:C base pairs found in the PHE-derived spectrum is likely due to oxidative damage as a result of induction of CYP2B isozymes by the chronic administration of PHE. Phenobarbital cytochrome P450, family 2, subfamily b, polypeptide 9 Mus musculus
2 It is postulated that the increase in transversions at G:C base pairs found in the PHE-derived spectrum is likely due to oxidative damage as a result of induction of CYP2B isozymes by the chronic administration of PHE. Phenobarbital cytochrome P450, family 2, subfamily b, polypeptide 9 Mus musculus
3 The PHE-derived spectrum of lacI mutants from the liver of Big Blue(R) B6C3F1 male mice was remarkably similar (p=0.8) to that generated by oxazepam (OX), a compound which also induces CYP2B isozymes following chronic administration of the drug. Phenobarbital cytochrome P450, family 2, subfamily b, polypeptide 9 Mus musculus