Title : Translational inhibition of E-selectin expression stimulates P-selectin-dependent neutrophil recruitment.

Pub. Date : 2000 Apr

PMID : 10749718






3 Functional Relationships(s)
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1 Surprisingly, inhibition of E-selectin expression with the general protein synthesis inhibitor cycloheximide induced P-selectin expression 4 h after thrombin stimulation. Cycloheximide coagulation factor II, thrombin Homo sapiens
2 Cycloheximide and thrombin (4 h) induced sufficient P-selectin-dependent rolling to recruit as many neutrophils as were recruited with 4 h of stimulation with thrombin alone. Cycloheximide coagulation factor II, thrombin Homo sapiens
3 Treatment of endothelium with tumor necrosis factor-alpha (an E-selectin inducer) and cycloheximide also eliminated E-selectin expression but, much like thrombin, induced P-selectin expression and neutrophil recruitment. Cycloheximide coagulation factor II, thrombin Homo sapiens