Pub. Date : 2000 Apr
PMID : 10749718
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Surprisingly, inhibition of E-selectin expression with the general protein synthesis inhibitor cycloheximide induced P-selectin expression 4 h after thrombin stimulation. | Cycloheximide | coagulation factor II, thrombin | Homo sapiens |
| 2 | Cycloheximide and thrombin (4 h) induced sufficient P-selectin-dependent rolling to recruit as many neutrophils as were recruited with 4 h of stimulation with thrombin alone. | Cycloheximide | coagulation factor II, thrombin | Homo sapiens |
| 3 | Treatment of endothelium with tumor necrosis factor-alpha (an E-selectin inducer) and cycloheximide also eliminated E-selectin expression but, much like thrombin, induced P-selectin expression and neutrophil recruitment. | Cycloheximide | coagulation factor II, thrombin | Homo sapiens |