Pub. Date : 2000 Mar
PMID : 10741630
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: Simvastatin is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase that is used as a cholesterol-lowering agent and is metabolized by cytochrome P450 3A (CYP3A) enzymes. | Simvastatin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | BACKGROUND: Simvastatin is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase that is used as a cholesterol-lowering agent and is metabolized by cytochrome P450 3A (CYP3A) enzymes. | Simvastatin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Diltiazem is a substrate and an inhibitor of CYP3A enzymes and is commonly coadministered with cholesterol-lowering agents such as simvastatin. | Simvastatin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | CONCLUSION: Diltiazem coadministration resulted in a significant interaction with simvastatin, probably by inhibiting CYP3A-mediated metabolism. | Simvastatin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | Concomitant use of diltiazem or other potent inhibitors of CYP3A with simvastatin should be avoided, or close clinical monitoring should be used. | Simvastatin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |