Title : Novel allocolchicinoids with an eight membered B-ring: design, synthesis and inhibition of tubulin assembly.

Pub. Date : 2000 Mar

PMID : 10732972






1 Functional Relationships(s)
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1 The amino-allocolchicinoid (9), a key compound in this study, was transformed to the highly potent ketone 10 and by oxidation with H2O2/Na2WO4 to a mixture of syn/anti-oximes, like 11 and 12. Ketones synemin Homo sapiens