Title : Sensitivity to CPT-11 of xenografted human colorectal cancers as a function of microsatellite instability and p53 status.

Pub. Date : 2000 Feb

PMID : 10732766






2 Functional Relationships(s)
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1 Sensitivity to CPT-11 of xenografted human colorectal cancers as a function of microsatellite instability and p53 status. Irinotecan tumor protein p53 Homo sapiens
2 Taken together, these observations indicate that MSI and p53 alterations could be associated with different CPT-11 sensitivities; MSI phenotype moderately influences the CPT-11 sensitivity, MSI+ being more sensitive than MSI(-)CRC freshly obtained from patients, mutp53 status being associated with a poor response to CPT-11. Irinotecan tumor protein p53 Homo sapiens