Title : Human metastatic prostate PC3 cell lines degrade bone using matrix metalloproteinases.

Pub. Date : 1998-1999

PMID : 10729774






1 Functional Relationships(s)
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1 A role for matrix metalloproteinases in degradation was shown by: (1) stimulation by the phorbol ester TPA of PC3-induced matrix degradation and release of matrix metalloproteinase activity; (2) abrogation of matrix degradation by 1,10-phenanthroline, a metalloproteinase inhibitor, and (3) degradation of purified type I collagen by PC3 cells and their conditioned medium. 1,10-phenanthroline proprotein convertase subtilisin/kexin type 1 Homo sapiens