Title : Corticotropin-releasing hormone gene expression in primary placental cells is modulated by cyclic adenosine 3',5'-monophosphate.

Pub. Date : 2000 Mar

PMID : 10720069






3 Functional Relationships(s)
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1 Both forskolin and 8-bromo-cAMP, activators of protein kinase A, can increase CRH promoter activity 5-fold in transiently transfected human primary placental cells, in a manner that parallels the increase in endogenous CRH peptide. 8-Bromo Cyclic Adenosine Monophosphate corticotropin releasing hormone Homo sapiens
2 Both forskolin and 8-bromo-cAMP, activators of protein kinase A, can increase CRH promoter activity 5-fold in transiently transfected human primary placental cells, in a manner that parallels the increase in endogenous CRH peptide. 8-Bromo Cyclic Adenosine Monophosphate corticotropin releasing hormone Homo sapiens
3 Maximal stimulation of CRH promoter activity occurs at 500 micromol/L 8-bromo-cAMP and 10 micromol/L forskolin. 8-Bromo Cyclic Adenosine Monophosphate corticotropin releasing hormone Homo sapiens