Pub. Date : 2000 Jan
PMID : 10718635
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ethanol and polyunsaturated fatty acids such as arachidonic acid were shown to be toxic and cause apoptosis in HepG2 cells which express CYP2E1 but not in control HepG2 cell lines. | Fatty Acids, Unsaturated | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 2 | These results extend previous observations found with HepG2 cells expressing CYP2E1 to intact hepatocytes and suggest that release of cytochrome c and activation of caspase 3 play a role in the overall pathway by which CYP2E1 contributes towards the hepatotoxic actions of ethanol and polyunsaturated fatty acids. | Fatty Acids, Unsaturated | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |