Title : Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide biosynthesis.

Pub. Date : 2000 Mar 15

PMID : 10706887






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 ATIC-ALK was constitutively tyrosine phosphorylated and could convert the IL-3-dependent murine hematopoietic cell line BaF3 to cytokine-independent growth. Tyrosine anaplastic lymphoma kinase Mus musculus