Pub. Date : 2000 Mar 15
PMID : 10706683
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thus, we tested the hypothesis that histamine inhibits the release of a proinflammatory cytokine, namely TNF, by stimulating the release of an anti-inflammatory cytokine, IL-10. | Histamine | interleukin 10 | Homo sapiens |
| 2 | Histamine treatment (10-5 M) increased the release of IL-10 from unstimulated (2.2-fold) and LPS-stimulated (1. | Histamine | interleukin 10 | Homo sapiens |
| 3 | Unstimulated AMs, NR8383, express few copies of IL-10 mRNA, as tested by quantitative PCR, but expression of IL-10 was increased by 1.5-fold with histamine treatment. | Histamine | interleukin 10 | Homo sapiens |
| 4 | Moreover, the stimulation of IL-10 release by histamine was abrogated by pretreatment with anti-PGE2 or the NO synthase inhibitor, Nomega-nitro-l -arginine methyl ester. | Histamine | interleukin 10 | Homo sapiens |
| 5 | Thus, histamine increases the synthesis and release of IL-10 from AMs through PGE2 and NO production. | Histamine | interleukin 10 | Homo sapiens |