Title : Inhibition of myeloma cell growth by all-trans retinoic acid is associated with upregulation of p21WAF1 and dephosphorylation of the retinoblastoma protein.

Pub. Date : 1999 Oct

PMID : 10706449






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The ATRA-mediated increase in p21 preceded the change in RB phosphorylation and G1 arrest and was not reversed by the addition of exogenous IL-6. Tretinoin H3 histone pseudogene 16 Homo sapiens
2 The levels of CDK2 activity were inhibited approximately 60% in ATRA-treated cells, suggesting that the increased p21 levels were sufficient to inhibit CDK activity and cause RB hypophosphorylation. Tretinoin H3 histone pseudogene 16 Homo sapiens