Pub. Date : 2000 Mar
PMID : 10704257
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Retinoic acid suppresses interleukin 6 production in normal human osteoblasts. | Tretinoin | interleukin 6 | Homo sapiens |
| 2 | Within 24 h, RA at all four concentrations reduced Il-6 production from normal human osteoblasts. | Tretinoin | interleukin 6 | Homo sapiens |
| 3 | The pharmacological concentration of 10(-5) M RA suppressed 90% of IL-6 production. | Tretinoin | interleukin 6 | Homo sapiens |
| 4 | The present study shows for the first time that RA profoundly inhibits IL-6 production in normal human osteoblasts within 24 h and in a dose-dependent manner. | Tretinoin | interleukin 6 | Homo sapiens |
| 5 | RA was shown previously to inhibit IL-6 production in several other normal and malignant human cell types. | Tretinoin | interleukin 6 | Homo sapiens |
| 6 | Thus, RA inhibition of IL-6 production in normal human osteoblasts may contribute to the bone abnormalities seen after systemic long-term retinoid therapy in some patients. | Tretinoin | interleukin 6 | Homo sapiens |