Title : Impaired endothelial function in transgenic mice expressing both human renin and human angiotensinogen.

Pub. Date : 2000 Mar

PMID : 10700516






1 Functional Relationships(s)
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1 RESULTS: After submaximal precontraction with U46619 or prostaglandin F(2alpha), acetylcholine, which produces relaxation mediated by endothelial nitric oxide synthase, produced marked relaxation of carotid arteries in control mice but was impaired in R+/A+ mice. 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid nitric oxide synthase 3, endothelial cell Mus musculus