Title : Comparison of Fas- versus perforin-mediated pathways of cytotoxicity in TCR- and Thy-1-activated murine T cells.

Pub. Date : 2000 Mar

PMID : 10700471






1 Functional Relationships(s)
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1 The data suggest that Thy-1-triggered Fas-mediated cytotoxicity is completely dependent on cross-talk between Thy-1 and TCR signals since mutations in TCR-CD3 complex molecules or inhibition of tyrosine kinases or calcineurin abolished or strongly inhibited Thy-1-triggered FasL-Fas-mediated cytotoxicity. ammonium ferrous sulfate Fas ligand (TNF superfamily, member 6) Mus musculus