Title : UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation.

Pub. Date : 2000 Mar 1

PMID : 10699952






4 Functional Relationships(s)
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1 Subsequent studies from other laboratories revealed that UCN-01 could selectively enhance cytotoxicity of DNA damaging agents in p53 defective cells and that this was mediated by abrogation of S and /or G(2) arrest by UCN-01. 7-hydroxystaurosporine tumor protein p53 Homo sapiens
2 Subsequent studies from other laboratories revealed that UCN-01 could selectively enhance cytotoxicity of DNA damaging agents in p53 defective cells and that this was mediated by abrogation of S and /or G(2) arrest by UCN-01. 7-hydroxystaurosporine tumor protein p53 Homo sapiens
3 In this study, we report that UCN-01 selectively enhances the cytotoxicity of MMC in human p53 mutant cell lines. 7-hydroxystaurosporine tumor protein p53 Homo sapiens
4 Detailed cell-cycle studies revealed that UCN-01 abrogated S and G(2) phase accumulation induced by MMC in p53 defective cells and to a lesser extent in p53 wild-type cell lines. 7-hydroxystaurosporine tumor protein p53 Homo sapiens