Pub. Date : 2000 Mar 1
PMID : 10699952
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Subsequent studies from other laboratories revealed that UCN-01 could selectively enhance cytotoxicity of DNA damaging agents in p53 defective cells and that this was mediated by abrogation of S and /or G(2) arrest by UCN-01. | 7-hydroxystaurosporine | tumor protein p53 | Homo sapiens |
| 2 | Subsequent studies from other laboratories revealed that UCN-01 could selectively enhance cytotoxicity of DNA damaging agents in p53 defective cells and that this was mediated by abrogation of S and /or G(2) arrest by UCN-01. | 7-hydroxystaurosporine | tumor protein p53 | Homo sapiens |
| 3 | In this study, we report that UCN-01 selectively enhances the cytotoxicity of MMC in human p53 mutant cell lines. | 7-hydroxystaurosporine | tumor protein p53 | Homo sapiens |
| 4 | Detailed cell-cycle studies revealed that UCN-01 abrogated S and G(2) phase accumulation induced by MMC in p53 defective cells and to a lesser extent in p53 wild-type cell lines. | 7-hydroxystaurosporine | tumor protein p53 | Homo sapiens |