Pub. Date : 2000 Feb 7
PMID : 10698448
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Four primary zinc-binding pharmacophores (thiols, carboxylates, phosphorus acids, and hydroxamates) have been utilized in generating inhibitors of zinc metalloproteases such as ACE, NEP, the MMPs, and ECE. | Sulfhydryl Compounds | angiotensin I converting enzyme | Homo sapiens |
| 2 | Although compounds which inhibit the activity of both ACE and NEP (vasopeptidase inhibitors, VPIs) have been reported which incorporate a thiol, carboxylate, or phosphorus acid pharmacophore, the generation of hydroxamate based vasopeptidase inhibitors has remained elusive. | Sulfhydryl Compounds | angiotensin I converting enzyme | Homo sapiens |