Title : N-formyl hydroxylamine containing dipeptides: generation of a new class of vasopeptidase inhibitors.

Pub. Date : 2000 Feb 7

PMID : 10698448






1 Functional Relationships(s)
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1 Although compounds which inhibit the activity of both ACE and NEP (vasopeptidase inhibitors, VPIs) have been reported which incorporate a thiol, carboxylate, or phosphorus acid pharmacophore, the generation of hydroxamate based vasopeptidase inhibitors has remained elusive. carboxylate angiotensin I converting enzyme Homo sapiens