Title : Prolidase as a prodrug converting enzyme. III. Synthesis of proline analogues of melphalan and theirs susceptibility to the action of prolidase.

Pub. Date : 1999

PMID : 10697434






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Synthesis of proline analogues of melphalan and theirs susceptibility to the action of prolidase. Proline peptidase D Homo sapiens
2 The synthesis of proline analogues of melphalan (well known antineoplastic agent) conjugated through imido-bond (potential target for prolidase action) has been performed. Proline peptidase D Homo sapiens
3 It suggests that targeting of prolidase as a proline analogue of melphalan-converting enzyme may serve as a novel strategy in therapy of neoplastic diseases. Proline peptidase D Homo sapiens