Title : Ifosfamide-based drug combinations: preclinical evaluation of drug interactions and translation into the clinic.

Pub. Date : 2000 Feb

PMID : 10697038






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Since adequate glutathione levels are necessary for multidrug resistance protein (MRP) function, glutathione depletion might lead to reversal of MRP-mediated drug resistance. Glutathione ATP binding cassette subfamily C member 1 Homo sapiens
2 Since adequate glutathione levels are necessary for multidrug resistance protein (MRP) function, glutathione depletion might lead to reversal of MRP-mediated drug resistance. Glutathione ATP binding cassette subfamily C member 1 Homo sapiens
3 Since adequate glutathione levels are necessary for multidrug resistance protein (MRP) function, glutathione depletion might lead to reversal of MRP-mediated drug resistance. Glutathione ATP binding cassette subfamily C member 1 Homo sapiens
4 Preliminary data showed that 4-OOH-IF significantly decreases glutathione concentrations in MRP-expressing human HT1080/DR4 sarcoma cells, leading to maximum steady-state reduction after a 90-min exposure to 4-OOH-IF. Glutathione ATP binding cassette subfamily C member 1 Homo sapiens