Title : Is estradiol a genotoxic mutagenic carcinogen?

Pub. Date : 2000 Feb

PMID : 10696569






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Tumors may be initiated by metabolic conversion of E2 to 4-hydroxyestradiol catalyzed by a specific 4-hydroxylase (CYP1B1) and by further activation of this catechol to reactive semiquinone/quinone intermediates. 4-hydroxyestradiol cytochrome P450 family 1 subfamily B member 1 Homo sapiens