Title : Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture.

Pub. Date : 2000 Mar

PMID : 10693931






3 Functional Relationships(s)
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1 Our results showed that exogenously added apoE promoted the efflux of cholesterol and phosphatidylcholine from both astrocytes and neurons in culture, resulting in the generation of high-density lipoprotein-like particles. Phosphatidylcholines apolipoprotein E Homo sapiens
2 In contrast, the efflux of both cholesterol and phosphatidylcholine promoted by apoE was abolished following treatment with heparinase or lactoferrin, which block the interaction of apoE with heparan sulfate proteoglycans (HSPGs) or low-density lipoprotein receptor-related protein (LRP), respectively. Phosphatidylcholines apolipoprotein E Homo sapiens
3 In contrast, the efflux of both cholesterol and phosphatidylcholine promoted by apoE was abolished following treatment with heparinase or lactoferrin, which block the interaction of apoE with heparan sulfate proteoglycans (HSPGs) or low-density lipoprotein receptor-related protein (LRP), respectively. Phosphatidylcholines apolipoprotein E Homo sapiens