Pub. Date : 2000 Apr 15
PMID : 10692561
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide. | Cyclophosphamide | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Analysis of a panel of fifteen human P450 cDNAs in the baculovirus expression system ("Supersomes") demonstrated that CYP3A4 exhibited the highest N-dechloroethylation activity toward both CPA and IFA, whereas CYP2B6 displayed high N-dechloroethylation activity toward IFA, but not CPA. | Cyclophosphamide | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Analysis of a panel of fifteen human P450 cDNAs in the baculovirus expression system ("Supersomes") demonstrated that CYP3A4 exhibited the highest N-dechloroethylation activity toward both CPA and IFA, whereas CYP2B6 displayed high N-dechloroethylation activity toward IFA, but not CPA. | Cyclophosphamide | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | With CPA as substrate, CYP3A4 was shown to catalyze >/=95% of liver microsomal N-dechloroethylation, whereas with IFA as substrate, CYP3A4 catalyzed an average of approximately 70% of liver microsomal N-dechloroethylation (range = 40-90%), with the balance of this activity catalyzed by CYP2B6 (range = 10-70%, dependent on the CYP2B6 content of the liver). | Cyclophosphamide | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |