Title : Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z, 13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2. Why acetylated COX-1 does not synthesize 15-(R)-hete.

Pub. Date : 2000 Mar 3

PMID : 10692466






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Acetylated COX-2 is essentially a lipoxygenase, making 15-(R)-hydroxyeicosatetraenoic acid (15-HETE) and 11-(R)-hydroxyeicosatetraenoic acid (11-HETE), whereas acetylated COX-1 is unable to oxidize arachidonic acid to any products. Arachidonic Acid cytochrome c oxidase I, mitochondrial Mus musculus