Title : Enhanced electron flux and reduced calmodulin dissociation may explain "calcium-independent" eNOS activation by phosphorylation.

Pub. Date : 2000 Mar 3

PMID : 10692402






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Enhanced electron flux and reduced calmodulin dissociation may explain "calcium-independent" eNOS activation by phosphorylation. Calcium nitric oxide synthase 3 Bos taurus
2 These results suggest that a negative charge imposed at serine 1179, either by phosphorylation or by replacement with aspartate, increases eNOS catalytic activity by increasing electron flux at the reductase domain and by reducing calmodulin dissociation from activated eNOS when calcium levels are low. Calcium nitric oxide synthase 3 Bos taurus
3 These results suggest that a negative charge imposed at serine 1179, either by phosphorylation or by replacement with aspartate, increases eNOS catalytic activity by increasing electron flux at the reductase domain and by reducing calmodulin dissociation from activated eNOS when calcium levels are low. Calcium nitric oxide synthase 3 Bos taurus