Pub. Date : 2000
PMID : 10686516
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of interleukin-6 and tumor necrosis factor-alpha on GABA release from mediobasal hypothalamus and posterior pituitary. | gamma-Aminobutyric Acid | interleukin 6 | Rattus norvegicus |
| 2 | We examined the effect of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) on release of gamma-aminobutyric acid (GABA) from mediobasal hypothalamic (MBH) explants and posterior pituitaries (PP) of male rats. | gamma-Aminobutyric Acid | interleukin 6 | Rattus norvegicus |
| 3 | IL-6 (10 ng/ml) did not modify basal GABA release from MBH and PP, but significantly increased GABA release under depolarizing conditions (40 mM K(+)). | gamma-Aminobutyric Acid | interleukin 6 | Rattus norvegicus |
| 4 | This effect was abolished by incubation of the tissue with indomethacin, an inhibitor of cyclooxygenase activity, indicating that prostaglandins could mediate the stimulation of GABA release induced by IL-6. | gamma-Aminobutyric Acid | interleukin 6 | Rattus norvegicus |
| 5 | The current results indicate that IL-6 stimulates GABA release from both hypothalamus and posterior pituitary by a mechanism mediated by prostaglandins. | gamma-Aminobutyric Acid | interleukin 6 | Rattus norvegicus |